BPC 157 is a short peptide chain — basically a piece of a protein. Its regenerative possible attracted scientists, who are beginning to investigate if this peptide will promote wound and muscle healing and counteract the toxic effects of ordinary painkillers. Read on to learn what the science does, and doesn’t, say about BPC 157.
What’s BPC 157?
BPC is a protein found in stomach acid also discovered from the’90s. BPC 157 is a 15-amino-acid-long fragment of this protein that’s synthetically produced.
Some studies refer to BPC as”body defense chemical,” hinting at its curative potential. Scientists consider this type of blueprint for an entirely new class of organ-protective/healing drugs, however, research is still in the early phases.
How Can BPC 157 Work?
BPC 157 likely promotes muscle and tendon healing by triggering the creation of new blood vessels — a process called angiogenesis (by upping VEGF). This clarifies its regenerative possible and why it may also help heal cuts, wounds, and other types of damage in your system.
By increasing new blood vessels, then it may assist with IBD, where healing of the inflamed gut lining is slow.
Also, BPC 157 may encourage wound and tendon healing by obstructing the growth-inhibiting ramifications of a certain molecule (called 4‐hydroxynonenal).
It might specifically help joints cure by inducing tendon cells to create more receptors for growth signaling molecules. This, in turn, enables the tendon cells to grow and continue during injury mend, speeding up the process.
Additionally, it may decrease inflammation, which is probably involved in its effects on wounds, ulcers, and tissue defense.
BPC 157 also can influence the activity of neurotransmitters like serotonin and dopamine. Subsequently, it may help with depression, seizures, pain, and may even promote bowel health. More study is required to understand precisely how it works in the brain.
Last, it can increase the production of nitric oxide (NO), which reduces blood pressure and helps to decrease the consequences of high potassium amounts.
Snapshot of BPC 157
- May promote healing and tissue regeneration
- May reduce inflammation
- May protect organs from toxins and damage
- No published, peer-reviewed studies in humans
- Unknown safety profile
- May interact with other drugs and medications
- Possible conflicts of interest for scientists doing the study
Benefits & Potential Uses of BPC 157
Animal and Cellular Research (Lack of Proof )
No clinical evidence supports the use of BPC 157 for any of the states listed in this part. Below is a summary of the present creature and cell-based research, which ought to guide further investigational efforts. On the other hand, the research listed should not be interpreted as supportive of any health benefit.
Inflammatory Bowel Disease
There are numerous references, both online and in published scientific research, to BPC 157 being safe and/or successful in clinical trials of inflammatory bowel disease (IBD). Yet, results from these studies don’t seem to have been printed or peer-reviewed.
Some studies in humans with names suggesting they tested IBD — cited even in the scientific study — were in fact performed in healthy people (see”Side Effects” section below).
Muscle and Tendon Healing
In rats with injuries in their Achilles tendons, shots together with BPC 157 assisted the joints to cure almost completely, whereas control rats did not make full recoveries.
Similarly, peptide injections enhanced muscle healing for rats whose muscles were crushed or cut. This effect even held true when rats were also treated with corticosteroids (steroid drugs such as hydrocortisone), which can slow the healing process.
Curing Burns, Cuts, and Broken Bones
In mice with burns, lotions containing BPC 157 accelerated the recovery process, even in people simultaneously given corticosteroids.
BPC 157 also helped reductions heal in mice and in rats. It was effective even in diabetic rats; diabetes may make it more difficult for the body to cure wounds.
Injections with the peptide also resisted the healing of broken bones in rabbits.
Assessing the Brain and Nervous System
Rats given BPC 157 injections after suffering traumatic brain injury had less brain damage, and rats injected with BPC 157 before brain trauma were more likely to remain conscious and not as likely to die.
In rats with nerve damage in their own legs, BPC 157 shots assisted the nerve cells to regrow and heal.
The peptide also protected mice from drug-induced seizures.
It may also positively affect mood. In 1 study, BPC 157 shots diminished melancholy -similar behavior in rats. This effect was comparable to that of conventional antidepressants.
Ulcers and Gut Health
Injections of BPC 157 helped to cure stomach ulcers in rats. It also protected the rats’ intestines from damage due to toxins like alcohol and aided heal gastrointestinal fistulas — abnormal openings in the digestive tract that cause fluids to flow.
In one study, BPC 157 shots reduced inflammation in rats with both stomach ulcers and arthritis.
In rats with an inflamed esophagus — the tube that goes from the throat into the stomach — the peptide also decreased inflammation.
Interestingly, BPC 157 might act on the gut-brain axis, helping to soothe the stress response “from the inside out”.
Damage Caused By NSAIDs
NSAIDs (non-steroidal anti-inflammatory medications ) include over-the-counter (OTC) pain medicines like aspirin and aspirin. Although generally safe if used as directed, these drugs can lead to damage to organs like the gut and liver if consumed in high doses.
BPC 157, either injected or consumed in drinking water, reversed these toxic effects in rats given NSAIDs.
BPC 157 might be useful in counteracting drug intoxication.
In rats, BPC 157 given with morphine made the morphine less powerful — that is, the rats given both the morphine and the peptide were more sensitive to pain compared to those given just morphine. However, rats given both were less sensitive to pain than rats given nothing whatsoever.
It also diminished strange behavior in rats given amphetamines. This peptide may counteract the chemical imbalances amphetamines can activate, particularly on the dopamine system.
BPC 157 alone might be a moderate painkiller. Rats injected with the peptide experienced less pain to pinching and similar unpleasant stimulation. Notably, this analysis was testing the effects of BPC 157 alone, not in combination with pain-reducing medications (i.e. morphine, mentioned above).
Balancing Blood Pressure
In rats, BPC 157 had a stabilizing effect on blood pressure: in people who have chemically induced elevated blood pressure, peptide injections decreased blood pressure. However, in rats given L-arginine, which could dangerously lower blood pressure, BPC 157 increased it.
Balancing Potassium Levels
Hyperkalemia is when blood potassium levels become too high. It’s normally the result of kidney disease, and it can lead to muscle weakness, fatigue, irregular heart rhythms (arrhythmias), and even death.
In one study, untreated rats with hyperkalemia died within half an hour. But rats given injections of BPC 157, either before or promptly after obtaining hyperkalemia, endured and had fewer symptoms.
BPC 157 Side Effects
Keep in mind the BPC 157 is a nearly researched substance. Due to the absence of clinical studies, its safety profile in humans remains unknown. Talk with your doctor before supplementing with this particular peptide and record any side effects that you notice after taking it.
In 1 study, 32 healthy male volunteers were given BPC 157 enemas and reportedly had no notable adverse effects. However, important details such as dosage are not readily available, and enemas are not the typical route of administration.
Additionally, these results seem to have only been demonstrated at conferences and haven’t yet gone through peer evaluation.
As there aren’t many strong scientific studies in humans, it’s unclear exactly what the side effects of BPC 157 are. Animal studies generally report no obvious adverse reactions, although that doesn’t exclude the possibility of unnoticed results or distinct effects in humans.
Peptides Negative Effects
Peptides used to increase muscle mass comes with numerous unwanted effects. While there are no statistics to say for certain whether BPC 157 will create the same, some of the side effects associated with using peptides include:
- Kidney and liver toxicity
- Unusual appetite and weight reduction
- Feeling sexy or cold
- blood pressure changes (increase or decrease, depending upon the peptide)
- Heart problems like abnormal rhythms
- Infection and dizziness
- Toxicity into fetuses
Furthermore, many peptides are proven to interact with drugs. Therefore, it is always best to ask a doctor prior to taking any peptide.
Growing new blood vessels is helpful in regards to injury repair, but it can be dangerous when it comes to cancer. While no studies suggest that BPC 157 raises the probability of cancer, its capacity to increase blood vessel development may feed existing tumors and induce them to disperse.
On the other hand, BPC 157 may actually be advantageous for decreasing muscle wasting in cancer sufferers. Research is now underway.
The Way to Take BPC 157
BPC 157 may be obtained orally or via injection, either subcutaneous (under the skin) or intramuscular (directly to the muscle).
Of course, shots of any material carry their own dangers and require medical supervision.
Anecdotally, several users report cycling BPC 157, while others use lower doses over extended periods of time (> 6 weeks ).
As there are no peer clinical trials analyzing BPC 157, there is absolutely no proven dose. Additionally, the FDA has approved this medication for any conditions nor recognized an official dose. Users and supplement manufacturers have established unofficial doses according to trial and error.
In mice and rats ingesting BPC 157 in their drinking water, the typical dosage ranged from 10 nanograms to 10 mcg (micrograms) per kg. The researched dosage for injections in rodents was within the same range.
This is equivalent to a maximal dose of approximately 600 mcg for a 60 kg (132 lbs) adult human.
However, doses frequently don’t scale between species. Some users report carrying lower doses (~250 mcg/day) for pain relief.
Recall that BPC 157 has not been studied in people. There’s not any way to know what the safe and efficient dosage would be before clinical trials are performed.
Furthermore, lots of the animal experiments were done using injections directly into the abdominal cavity, rather than under the skin or to the muscle.
Limitations and Caveats
First and foremost, all the research discussed above were conducted in animal versions and/or in cells in dishes. While such studies can be valuable, mice are not the same as individuals, so it is important not to presume that a treatment is going to have an identical impact on both species.
Additionally, most of the studies were performed by the exact same few labs, using the very same people listed as co-authors in many studies.
While it isn’t unusual for a laboratory that finds an intriguing avenue of study like BPC 157 to”take it and run with it,” this will raise the chances for bias, especially when a few of the researchers hold patents on the chemicals being analyzed.
BPC 157 Reviews & User Risks
The opinions expressed in this section are only those of BPC 157 users, who might or might not have scientific or medical training. Their testimonials don’t reflect the opinions of SelfHacked. SelfHacked doesn’t endorse any particular product, service, or treatment, especially the ones that haven’t been studied in humans.
Don’t consider user experiences as medical information. Never delay or disregard seeking professional medical advice from your health care provider or other qualified healthcare providers because of something you have read on SelfHacked. We know that studying individual, real-life encounters can be a helpful resource, but it’s never a substitute for professional medical advice, diagnosis, or therapy from a qualified healthcare provider.
Generally, users of BPC 157 report positive effects. In professional muscle building forums, users report that the peptide can aid with healing injuries, soreness, inflammation, and tendonitis. 1 user said, “I give it all of the glory.”
Some users have reported getting no noticeable advantage from using the peptide, and many voiced concerns over the high cost and confusion in how to utilize it and what the dosage should be. Some also reported unpleasant side effects, chiefly constipation. Others were concerned about the long-term security risks, given that this peptide hasn’t been examined in people.
Additionally, many users speculated that companies have mislabeled peptides that are more economical to manufacture as BPC 157, advocating caution for others looking to buy it.
BPC 157 is a peptide that’s been reported to have particular regenerative properties, from diminishing inflammation to protecting organs from harm to recovery wounds and tendons.
Studies in animal models show the promise of the peptide, but clinical studies are lacking.